In 1897, at a time when society was dominated by the belief that "the only science for women is cooking" she excelled and became the first woman to graduate from the Medical School of the University of Athens In 1893, medical students were enraged when they saw the young Angeliki Panagiotatou walk through the doors of the Athens Medical School. "When they were performing in the auditorium.. Grigoris Xenopoulos will write a few years later in "Children's Body" ,  they were clapping and shouting "In the kitchen..in the kitchen!!" Zacharias Papantoniou's fellow student will characteristically say "Aggeliki Panagiotatou made sure to join the class with the professors, this woman studied under the sound of foot clapping for four years"

After her studies, still unable to work in Greece, she left for Egypt, where she stayed and studied tropical diseases.

In 1902 she was honored in Egypt with the Order of the Nile,

 In 1908 she became the first assistant professor of Medicine at the University of Athens

In 1938 the first extraordinary professor of Hygiene and Tropical Pathology

In 1947, the first female regular professor of the School of Medicine of the University of Athens

 In 1950, the first female doctor and member of the Academy of Athens.

She wrote medical books and had a huge task as Director of the "Health Polyclinic" of the City Hall of Alexandria. She is considered the most important personality of Egyptian Hellenism of the 20th century and contributed a lot to the dissemination and preservation of its culture, as well as her own property in the Greek Community of Alexandria. Eleftherios Venizelos was the one who supported Panagiotatou and called her teaching "wise".